This study involved 22,000 healthy male physicians in the United States and found that men with baseline CRP values in the highest quartile had a threefold higher risk of acute coronary syndrome (MI; relative risk of 2.9) and a twofold higher risk of acute stroke (relative risk of 1.9) when compared with men in the lowest quartile of CRP values. The gene discussed is CRP; the disease is acute coronary syndrome.