METTL3 (methyltransferase−like 3, also termed MTA70), a methyltransferase responsible for N6−methyladenosine (m6A) modification, plays key regulatory roles in RNA stability, splicing and translation, and is involved in the cell differentiation and reprogramming, embryonic development and tumor progression [1,2,3,4,5,6]. The gene discussed is METTL3; the disease is neoplasm.