Regarding the participation of SPMs in macrophage polarization and their role in chronic liver disease, Kang et al., in a murine model of hepatic inflammation induced by ischemia-reperfusion, where an M1 polarization of the KCs is favored, demonstrated the pro-resolving and anti-inflammatory effects of RvD1 through the activation of ALX/FPR2 pathways [106]. This evidence concerns the gene FPR2 and inflammatory response.