TNF and viral infectious disease: Additionally, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis in both cell lines indicated pathways perturbed in shZNF714 cells, including cell adhesion, Extracellular Matrix (ECM)–receptor interaction, Tumor Necrosis Factor (TNF) signaling, various metabolic pathways [e.g., calcium signaling, Advanced Glycation Endproducts (AGE)-Receptor for AGE (RAGE) signaling pathway in diabetic complications], and disease-related pathways (e.g., cardiomyopathy, viral infections) (Figure 4E).