WNK2 and cancer: Moreover, in H2073 shZNF714 we observed overrepresentation of the pathways in cancer, pathways related to small lung cancer, and Mitogen-Activated Protein Kinase (MAPK) and Phosphoinositide 3 Kinase (PI3K)-Serine-Threonine Protein Kinase (Akt) signaling (Figure 4E).