JUN and malignant colon neoplasm: Figure 1) directly inhibits TOPK activity in vitro and in vivo, and is effective in suppressing colon cancer cell growth and inducing the apoptosis of colon cancer cells [14]. Recently, Roh et al. [15] demonstrated that HI-TOPK-032 can suppress UV-induced SCC through the TOPK-c–Jun axis and its topical application can be used as a potential chemopreventive drug against SCC development.