LGALS3 and stroke disorder: In recent years, a study on the delayed use of Gal3 after stroke demonstrated that the additional supplement of Gal3 increased microglial branching and mobility, altered cytokine expression profiles, and increased levels of anti-inflammatory factors such as IL-4 while decreasing the levels of pro-inflammatory factors such as TNF-α, IL-1β, IFN-γ, and IL-17 both in vivo and in vitro [78].