LGALS3 and Cerebral ischemia: In a study using a model of cerebral ischemia and neuroinflammation, after intraperitoneal injection of lipopolysaccharide, Gal3 released by microglia was upgraded, and it played a neuroprotective and anti-inflammatory role through its CRD as an endogenous paracrine signaling ligand of TLR4 [35].