When GSK-3b activity is blocked by the Gal3/PI3K/AKT signaling pathway, the b-catenin-Gal3 complex translocates to the nucleus, binding with the TCF/Lef transcription factor family and activating the expression of target genes including c-myc, cell cyclin D1/D2, MMP7, CD44, and other TCF/Lef response genes related to cancer progression [59,66]. Here, LGALS3 is linked to cancer.