Compounding this challenge, the pancreatic tumor cells themselves produce and release potent immunosuppressive agents, such as Transforming Growth Factor-beta (TGF-β), Interleukin-10 (IL-10), Interleukin-6 (IL-6), Vascular Endothelial Growth Factor (VEGF), and the Fas ligand [38,39]. This evidence concerns the gene IL10 and pancreatic neoplasm.