Furthermore, the administration of adiponectin in thioacetamide-induced HCC rats, which, however, does not represent an experimental NAFLD model, reversed liver tumors, which was mechanistically linked to the induction of apoptotic pathways through the restoration of p53 and TNF-related apoptosis-inducing ligand (TRAIL) activities, while reducing JNK expression [61], which as mentioned above, is commonly activated in HCC [25]. This evidence concerns the gene TP53 and hepatocellular carcinoma.