ADIPOQ and metabolic dysfunction-associated steatohepatitis: In addition, hypoadiponectinemia with adiponectin knockout in mice with choline-deficient L-amino acid-defined (CDAA) diet-induced NAFLD enhanced the progression to NASH and hepatic tumor formation [59], which was also confirmed by a subsequent study with adiponectin knockout mice on high fat diet (HFD) mice [60].