Similarly, thioacetamide-induced HCC rats treated with adiponectin presented an 80% increase in survival rate, a 73% reduction in average number of liver nodules, 46% decrease in serum alpha-fetoprotein (AFP), as well as a reduced expression of tumor invasion markers, TNF-α and NF-κΒ [62]. The gene discussed is TNF; the disease is hepatocellular carcinoma.