CD8A and neoplasm: This crosstalk between metabolic signals, inflammatory mediators, tumor cells, and immune cells appears to promote an immune-suppressive microenvironment, where several suppressive cells, such as neutrophils, tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), and B cells infiltrate into the tumor and impair the anti-tumor surveillance properties of CD8+ T cells, the main cytotoxic cells against malignant hepatocytes [29].