TNF-α, a key proinflammatory cytokine, and adiponectin, a key adipokine, are implicated in the pathogenesis of NAFLD and possibly in the progression to advanced disease, including NAFLD-associated HCC, which is supported by most of the current experimental and limited observational studies [8,9,10]. The gene discussed is ADIPOQ; the disease is metabolic dysfunction-associated steatotic liver disease.