In NAFLD, TNF-α may originate from several sources: the dysfunctional adipocytes, lipid-stressed hepatocytes, and various immune cells, including both innate immune cells (Kupffer cells (KCs), myeloid-derived monocytes, and neutrophils) and adaptive immune cells (i.e., natural killer (NK)T cells, CD8+, and CD4+ Th1 lymphocytes) that infiltrate the steatotic liver [13,14]. This evidence concerns the gene TNF and metabolic dysfunction-associated steatotic liver disease.