CXCL12 and neoplasm: (CXCL10) Inducing intracellular calcium influx, DNA synthesis, cell proliferation, and chemotaxis; (CXCL12) cell migration and its binding to the CXCR4 receptor is involved in the process of tumor growth, angiogenesis, and metastasis; (CCL21) chemoattractant to guide naïve CCR7 expressing T cells to the T-cell zone.