In the TME, TAMs secrete various cytokines, chemokines, and enzymes, such as, e.g., TGF-β, prostaglandins, IL-10, CCL22, CCL17, galectin-3 (Gal-3), and metalloproteinases (MMP), that induce immunosuppression by the activation of regulatory T cells (TREG), which, in consequence, lead to the loss of T cell function to recognize and kill tumor cells [1,26,27]. Here, LGALS3 is linked to neoplasm.