VSIR and neoplasm: Many other suppressive markers, interacting with tumor cells, are observed in TAM, such as, for example, (1) programmed death cell receptor 1 (PD-1), a PD-L1 ligand in tumor cells; (2) CD80, a CD28/cytotoxic T lymphocyte Associated Protein 4 (CTLA-4) ligand; (3) V-domain Ig suppressor of T cell activation (VISTA); (4) signal regulatory protein alpha (SIRPA), a ligand for the CD47 receptor; (5) leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1), an MHC-I ligand; or (6) sialic acid-binding Ig-like lectin 10 (Siglec-10), a CD24 ligand [1,2].