IL34 and osteosarcoma: On the other hand, IL-34 has been reported to induce vasculogenesis and tumor growth in osteosarcoma through the activation of endothelial cell signaling pathways, including the proto-oncogene tyrosine protein kinase Src (Src), focal adhesion kinase (FAK), and MAPKs, involved in angiogenesis and vascular homeostasis [41].