NOTCH1 and neoplasm: In tumor development are also involved other factors secreted by TAMs, eg IL-10, that support tumor growth and aggressiveness through the PI3K signaling pathway and the Janus-Activated Kinase (JAK)1/STAT1/NF-kB/neurogenic locus homolog protein 1 (Notch1) pathway [1,10], or CCL2, which activates the PI3K/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) [10].