Mantovani et al. [17], additionally divided M2 macrophages into four subtypes: M2a (induced by fungal and helminth infections, IL-4 and IL-13), M2b (induced by an immune complex and LPS), M2c (induced by IL-10, TGF- β, and glucocorticoids (GC)), and M2d (induced by IL-6 and adenosine) [17,18]. This evidence concerns the gene IL4 and helminthiasis.