Furthermore, through the secretion of adrenomedullin and vascular epithelial growth factors (VEGFs), and the expression of several immunosuppressive molecules (such as IL-10, programmed death-ligand 1 (PD-L1), or TGF-β, promoting tumor growth), M2 macrophages support angiogenesis in cancer cells [13,16]. This evidence concerns the gene TGFB1 and neoplasm.