Clinical: N/APathological: ER, PR, and Ki67 indexRadiomics: tumor stiffness (E) at different time points: before NACT (E0), after 1st & 2nd cycles (E1,E2), and before surgery(E6), in addition to their relative changes from baseline (ΔE1, ΔE2, ΔE6). Here, ESR1 is linked to neoplasm.