ESR1 and neoplasm: The prediction performance of:Pathological2 model: (based on ER, HER2) AUC: 0.717, SEN: 76.2%, SPE: 61.9%Pathological4 model: (PR, HER2, reduction of tumor volume) AUC: 0.825, SEN: 61.9%, SPE: 76.2%DLR2: AUC: 0.812, SEN: 90.5%, SPE: 47.6%DLR4: AUC: 0.937, SEN: 81%, SPE: 90.5%.They concluded that depending on pathological markers only is not reliable enough for response prediction, while DLRP can effectively aid in early stepwise prediction. Moreover, hybrid models (pathological + DLR) showed no improvements in the AUC.