KMT2A and leukemia: Moreover, similar interactions between AF9/ENL AHD and histone-H3 lysine-79 (H3K79) methyltransferase DOT1L (which also contains several LxVxIxLxxV/L sequences) can recruit DOT1L to MLL target gene loci, causing genome-wide H3K79 hypermethylation, which has been observed and characteristic to MLL-r leukemia [29].