Transcriptome-wide RNA profiling identified 85 high-confidence splicing events regulated by ADAR1 and ADAR2 in esophageal squamous carcinoma (ESCC) cells [75], revealing the effect of editing on auxiliary cis-acting elements, which, in turn, impacts splicing factors binding affinity. Here, ADARB1 is linked to esophageal squamous cell carcinoma.