Moreover, preclinical studies using the combination of PLK1 inhibitors, such as volasertib, along with other agents, such as etoposide, vincristine, vinblastine, vinorelbine, or eribulin, is widely beneficial in treating young patients with rhabdomyosarcoma and other cancers [331,332,333]. This evidence concerns the gene PLK1 and rhabdomyosarcoma.