The study by Lin Chen et al. further showed that the overexpression of MiR-203a-3p suppressed Phosphodiesterase 4D (PDE4D), resulting in increased expression levels of beta-catenin, c-Myc, and cyclin D1, in turn promoting colorectal carcinoma cell proliferation and migration [48]. Here, CTNNB1 is linked to colorectal carcinoma.