Collectively, these experiments (Supplementary Figure S2) provide clear evidence that Hsp90 does not activate proLOXL2 and Hsp90-proLOXL2 interaction, and subsequent activation to LOXL2 does not change the alignment of Collagen-1 fibers or the invasiveness of breast cancer cells through Collagen-1 fibers. The gene discussed is HSP90AA1; the disease is breast cancer.