VEGFA and metastatic malignant neoplasm in the lymph nodes: Furthermore, pre-clinical data concerning the VEGF role in GEP-NETs seems promising, as patients with metastatic disease had higher VEGF serum values when compared to patients without metastases (p = 0.033), and the highest levels were observed in the case of lymph node metastases (p = 0.008) [115].