Knockdown of CD47 using shRNA or siRNA in A549 cells or tumor xenografts, as well as shRNA in a Kras–Trp53-driven genetically engineered mouse model of LUAD, was found to increase phagocytosis of lung cancer cells by macrophages, reduce tumor growth, and prolong the survival of tumor-bearing mice [126,164,238]. The gene discussed is CD47; the disease is neoplasm.