Moreover, several studies demonstrated that aberrant expression of particular CA isoforms, including the cytosolic CAII and transmembrane CAIX isozymes, may provide prognostic value for patients with soft-tissue sarcoma [16,17,18]; however, to the best of our knowledge, there are no data on whether CA inhibition would be beneficial for the therapy of Ewing sarcoma cells under normoxic conditions. The gene discussed is CA2; the disease is Ewing sarcoma.