Furthermore, Gene Ontology-based analysis of the 50 most regulated genes in CAII-positive Ewing sarcoma tissue (using String software) is shown in Figure 1D. This analysis suggests a direct association of CAII with genes involved in angiogenesis (GO: 0001525, FDR 2.3 × 10−5, and GO: 0001568, FDR 1.8 × 10−8) and cellular migration (GO: 0010632, FDR 0.00022, and GO: 0030334, FDR 0.00045). Here, CA2 is linked to Ewing sarcoma.