These include common associations such as hypertension from tyrosine kinase inhibitors, heart failure from anthracyclines and trastuzumab, vasospasm from 5-fluorouracil and its derivatives, ischemia from vascular endothelial growth factor inhibition, and even myocarditis and accelerated atherosclerosis from newer agents such as immune-checkpoint inhibitors [20,21,22]. The gene discussed is VEGFA; the disease is ischemia.