In the integrative transcriptome analysis cohort, ESRRG, ZC3H8, RIMBP2, GPT2, STRBP, HTATSF1, TRIM45, SSX2IP, and PSRC1 were up-regulated while ZNF597, EFNB2, PLLP, NR1H3, EFHC2, and CFAP126 were down-regulated genes in SCLC tumor tissues compared to non-tumoral lung tissues. This evidence concerns the gene RIMBP2 and neoplasm.