CD274 and neoplasm: Meanwhile, for newly diagnosed patients treated with ICI plus chemotherapy, there were no differences in the CR rate according to differing PD-L1 protein expression or tumour MHC-I or MHC-II expression in patients with early-stage disease; however, there was an association between deeper and more durable responses and higher PD-L1 IHC expression on HRSCs in patients with advanced-stage disease.