However, the occurrence of reduced hemoglobin [24,29,32], positive QuantiFERON-TB Gold [29]; elevated LDH and lambda IgA [35], increased soluble interleukin 2 (IL-2) receptor [43], elevated CRP [32], increased ESR [28,32], and leukocytosis and changes in biochemical markers of cardiovascular damage [28] should be noted, in addition to leukopenia associated with thrombocytopenia [24]. The gene discussed is CRP; the disease is Decreased total leukocyte count.