Gene set enrichment analysis (GSEA) further revealed that proliferation, ribosome biogenesis, metastasis, and epithelial mesenchymal transition were enriched in the RNF149-high group (Figure 3C), suggesting that the high expression of RNF149 was related to the activation of proliferation, migration, and invasion of HCC. The gene discussed is RNF149; the disease is hepatocellular carcinoma.