Cluster 1B tumors bear PVs in the von Hippel–Lindau (VHL) tumor suppressor gene, HIF-2α encoding gene HIF2α/EPAS1, or the Egl-9 prolyl hydroxylase-1 and -2 encoding gene (EGLN 1/2 encoding PHD 1/2) [2,7,9]. This evidence concerns the gene EPAS1 and neoplasm.