IFNA1 and neoplasm: In the same study, single-cell RNA sequencing of 23 paired pretreatment and day 15 on-treatment tumor biopsies revealed induction of tumor-cell-intrinsic immune programs (such as types I and II IFN response, antigen-presenting genes, and T-cell-recruiting chemokines) and a more complete MAPK inhibition in patients with better clinical outcome.