A study by Keshinro A et al. on 499 CRC cases, including 11 POLE/POLD1-mutated tumors, showed higher rates of TILs in POLE- and POLD-mutated tumors (82%) in comparison with MSI-H (68%) and non-MSI-H CRC (4.5%) [165]. The gene discussed is POLE; the disease is colorectal carcinoma.