However, a retrospective Dutch cohort of 1250 patients with unresectable locally advanced melanoma treated with ICIs suggested that management of irAEs utilizing a combination of infliximab and corticosteroids was associated with shorter OS compared with corticosteroids alone, although the authors commented that a limitation of their study was that most of the anti-TNF–treated cohort also received high-dose steroids [36]. Here, TNF is linked to melanoma.