However, mir-144/miR-451a overexpression was shown to impair the M2 phenotype and, conversely, to be determinant in the stimulation of M1 repolarization of TAMs by targeting the secretion of HGF and MIF from HCC cells resulting in restored phagocytosis and an enhanced capability to activate cytotoxic T lymphocytes [146]. Here, HGF is linked to hepatocellular carcinoma.