In the HCC microenvironment, various overexpressed miRNAs favor tumor progression; in particular, miR-221 [targeting TIMP1/PTEN (AkT), and DDIT4 (mTOR) pathways] [25], miR-302d (targeting TGFBR2) [42], miR-96 (targeting Caspase-9) [43], miR-25 (targeting TRAIL) [44], and miR-92a (targeting FBXW7) [45] impact on cancer cell proliferation and survival mechanisms, whereas miR-130 (targeting HOXA5) [46] and miR-210 (targeting FGFRL1) [47] are principally involved in promoting angiogenesis. This evidence concerns the gene PTEN and cancer.