CDC42 and hepatocellular carcinoma: In HCC cells, the downregulation of miR-195 (targeting CDC42 and other proteins regulating the cell cycle) [19], miR-15b (targeting Bcl2) [54], miR-26a (targeting ULK1) [55], miR-766 and miR-148 (influencing the β-catenin/Wnt pathway) [56,57] represents dramatic events for the loss of control of proliferation/survival mechanisms.