In brilliant research by Wang and coworkers, the choline-deficient and amino-acid-defined (CDAA) diet of 84 weeks, a regimen able to promote nonalcoholic steatohepatitis (NASH)-induced hepatocarcinogenesis, was associated with a significant upregulation of miR-155 in C57BL/6 mice, contemporarily with a reduced expression of its natural target CCAAT/enhancer binding protein beta (C/EBPbeta), a key transcription factor regulating the proliferation and differentiation of multiple cell types [74]. This evidence concerns the gene CEBPB and metabolic dysfunction-associated steatohepatitis.