Acetyl-CoA abundance is elevated in acinar cells of the pancreatic cancer mouse model called KC (Pdx1-Cre; lox-stop-lox-KrasG12D/+), and acetyl-CoA in the cholesterol biosynthesis pathway supports acinar-to-ductal metaplasia (ADM) formation [9]. The gene discussed is PDX1; the disease is familial pancreatic carcinoma.