Yet, it has been shown that Ldlr, Apob, and Apoe genes are upregulated in pancreatic cancer in an oncogenic mouse model (Pdx1-Cre; lox-stop-lox-KrasG12D/+; Ink4a/Arflox/lox) compared to control mice [23]. Here, LDLR is linked to familial pancreatic carcinoma.