Interestingly, in murine pancreatic cancer autochthonous model (Ptf1a-Cre; lox-stop-lox-KrasG12D/+; Trp53lox/+), CRISPR-Cas9 screening for targeting ca. 3000 metabolic genes identified Fdft1 as one of the most differentially dependent genes in vivo. The gene discussed is PTF1A; the disease is familial pancreatic carcinoma.