Significant differences were noted when comparing OS between left-sided CRC and right-sided CC (Table 2 and Figure 2) in the TP53 non-GOF variant (median OS: 31.1 vs. 22.3 months, p = 0.02) (Figure 2a), KRAS wild-type (median OS: 30.7 vs. 25.3 months, p = 0.04) (Figure 2b), NOTCH1 wild-type (median OS: 29.5 vs. 25.2 months, p = 0.04) (Figure 2c), NOTCH1 covariant (median OS: 16.8 vs. 31.2 months, p = 0.03) (Figure 2c), NOTCH3 sole variant (median OS: not reached vs. 26.5 months, p = 0.01) (Figure 2d), and MYC amplification (median OS: 23.6 vs. 11.7 months, p = 0.01) (Figure 2e). The gene discussed is NOTCH1; the disease is colorectal carcinoma.