ATRX and neoplasm: Likewise, the loss of DAXX IHC expression was observed in 64 out of 100 cases of grade 1 and 2 primary PanNET specimens [66] and 16/105 PanNET specimens in a similar study [67] which reported that while the loss of DAXX expression alone did not significantly correlate with poor patients’ OS, the loss of either DAXX or ATRX was associated with higher Ki67 proliferative index, high tumor grade, nodal involvement, higher disease stage, infiltrative borders, and lymphovascular invasion.