Moreover, the microenvironment and cell-to-cell crosstalk may also contribute to an increase in the CLL autocrine production of cytokines and ILs, such as IL-2 [34], IL-8 [35,36], and TNF-α [37,38], that have been shown to be involved in CLL survival and disease progression. This evidence concerns the gene TNF and B-cell chronic lymphocytic leukemia.