SELL and B-cell chronic lymphocytic leukemia: Recently, an in vivo functional study using intravital microscopy and multiphoton imaging has shown that L-selectin mediates the interaction between CLL cells and the high endothelial venules (HEV) of the LNs and is required for the first step of CLL TEM, indicating that L-selectin could represent a valuable target to inhibit CLL homing into the LNs [125].