VLA-4 is capable of reducing spontaneous apoptosis in vitro in CLL cells cultured in the presence of its recombinant ligands, such as VCAM-1, fibronectin, and the globular C1q (gC1q) domain of elastin microfibrilinterfacer-1 (EMILIN-1) [178,179]. Here, FN1 is linked to B-cell chronic lymphocytic leukemia.