CD44 and B-cell chronic lymphocytic leukemia: To add another level of complexity, it has been shown that the CLL activation status influences the expression and the post-translational modifications of the CD44 variants, as CLL activation by CD40L induces the expression of CD44v3 and CD44v6 variants and also the N-linked glycosylation of the latter, which increases binding to HA and stromal cells [135].