The expression level of Lcn-2 in the bile of cholangiocarcinoma (CCA) patients was significantly higher than in control groups, while Lcn-2 knock-down inhibited cell growth in vitro and in vivo, while the overexpression of Lcn-2 increased the cell metastatic potential, making it overall a potentially prognostic marker for this disease [112]. Here, LCN2 is linked to cholangiocarcinoma.