Further, a study by Han and colleagues showed similar effects in gastric cancer cells (MGC-803), whereby the cancer cells were treated with Lcn-2-siRNA plasmids, resulting in the inhibition of cell proliferation, decreased expression of NF-κB and B-cell lymphoma-2 (Bcl-2), enhanced apoptosis, and the increased expression of Bcl2-associated X (Bax) [125]. The gene discussed is LCN2; the disease is cancer.