Whilst there are some conflicting data on the role of Lcn-2 and its inhibition of epithelial-to-mesenchymal transition (EMT) in hepatocellular carcinoma, Molina et al. suggested that hepatocyte-derived Lcn-2 could serve as a potential serum biomarker in HB [113]. Here, LCN2 is linked to hepatocellular carcinoma.