Bauer et al. assessed Lcn-2 expression in a representative cohort of 207 breast cancer patients, whereby a strong association was found between Lcn-2 expression and prognostic factors such as the Ki-67 proliferation index, lymph node involvement, and human epidermal growth factor receptor 2 (HER-2/neu) status and histological grade [51]. This evidence concerns the gene ERBB2 and breast carcinoma.