CD274 and neoplasm: Due to the absence of PD-L1 expression in the well-differentiated component, Ono et al. suggested that for this neoplasm, the use of immune checkpoint inhibitors in combination with other conventional chemotherapeutic agents, such as paclitaxel plus carboplatin and cisplatin which could provide more satisfactory results, had an action on the growth of the well-differentiated component [84].