POLE and neoplasm: Although in the series of high-grade endometrial carcinoma with POLE mutation of Concin et al. and Yu et al., there were only a few cases of EDC and EUC; these authors suggested that in cases with concomitant POLEMut and P53abn, the patients could be managed similarly to patients with POLEmut neoplasms, since the prognosis remained good [91,92].