Risk factors associated with patient treatment: increased toxicity of chemotherapeutic agents used; failure to receive GCSF/EPO prophylaxis; age over 72 years; aggressive primary tumour type, advanced stage, more organs involved; fragile laboratory values; haemoglobin < 10–11 g/dL, creatinine clearance < 34 mL/min; hearing loss; limited walking distance; need for assistance with basic activities of daily living and medication; reduced social activities and depression. The gene discussed is EPO; the disease is major depressive disorder.