AFP and neoplasm: In the univariate analysis, a max tumor size >5 cm (HR = 0.53, 95% CI: 0.29–0.58, p = 0.04), presence of extrahepatic metastasis (HR = 1.95, 95% CI: 1.03–3.68, p = 0.04), combined TACE /HAIC (HR = 0.50, 95% CI: 0.27–0.91, p = 0.02), WBC ≥ 10 × 109/L (HR = 3.63, 95% CI: 1.46–8.99, p = 0.01), NEUT ≥ 6.4 × 109/L (HR = 2.34, 95% CI: 1.11–4.94, p = 0.03) and AFP response (HR = 0.52, 95% CI: 0.27–0.91, p = 0.04) were associated with PFS (Figure 2).