By conducting a meta-analysis of 47 relevant cohort studies and analyzing 18 risk factors, Ma D et al. identified AFP, albumin-bilirubin score (ALBI), NLR, ECOG performance status, ChildPugh stage, BCLC stage, tumor number and vascular invasion as predictors for the PFS model, with AUC values of 0.575, 0.749 and 0.691 at 1-year, 2-year and 3-year follow-up points [45]. The gene discussed is ALB; the disease is neoplasm.