APC and neoplasm: Near-infrared photoimmunotherapy (NIR-PIT), which is a photo-activated cancer treatment based on the photo-induced ligand release reaction, is an emerging treatment modality which utilizes a light-activatable dye IRDye700Dx (IR700) conjugated to a monoclonal antibody (antibody–photoabsorber conjugate; APC) targeted against tumor-associated antigens located on the cell surface of tumor cells [20].