The most frequently determined test between 2018 and 2021 was CEA for colorectal cancer (22,583, 43.9% of all TM), followed by CA125 (9082, 17.7%), CA15-3 (8118, 15.8%), CA19-9 (7672, 14.9%), Calcitonin (1414, 2.8%), NSE (1303, 2.5%) and CA72-4 (1223, 2.4%), respectively (Table 2). Here, CALCA is linked to colorectal cancer.