The biodistribution, safety and tumor detection ability of 68Ga-NOTA-AE105 have been investigated in a phase I study [16], and recent phase II studies have shown the significant prognostic value of uPAR-PET/CT in patients with HNSCC [17] and in patients with neuroendocrine neoplasms [18]. Here, PLAUR is linked to head and neck squamous cell carcinoma.