RUNX2 and breast carcinoma: For instance, Meyer et al. discovered that two SNPs within intron 2 of the fibroblast growth factor receptor 2 (FGFR2) gene regulate FGFR2 gene expression by impacting the binding affinity of transcription factors Oct-1/Runt-related transcription factor 2 and CCAAT enhancer binding proteins, and thereby influence the risk of human breast cancer [53].