These immunomodulatory effects can result in a suppression of the immune system, producing direct and indirect pro-tumour effects such as tumour angiogenesis, the activation of 2-adrenergic and cyclooxygenase-2 receptors, the release of coagulation factors, and the depletion of natural killer cell (lymphocytes CD3- and CD56+) activity [18], which plays a significant role in anti-tumour immunity by controlling the dissemination of cancer cells [27,28]. This evidence concerns the gene NCAM1 and neoplasm.