GLRX3 and heart failure: Accordingly, cardiac ablation of another member of this family, Grx3, in young cardiac‐specific Grx3 knockout (Grx3‐KO) mice has been associated with left ventricular hypertrophy and heart failure (HF), while wild‐type mice exhibited lower levels of ROS and thereby normal Ca2+ handling in cardiomyocytes (Donelson et al., 2019; Ogata et al., 2021).