Therefore, this study attempts to detect the relationship between serum albumin levels and the risk of all-cause death, and to explore the additional effects of CMDs on such an association in the community-based centenarians, using data from the China Hainan Centenarian Cohort Study (CHCCS), to provide ideas for the early identification and intervention of hypoalbuminemia in the centenarians. This evidence concerns the gene ALB and Hypoalbuminemia.