In this study, we demonstrated for the first time that tumor cells actively sorted the tumor-suppressive miR-184-3p into exosomes through hnRNPA2B1, and up-regulated the transcriptional co-activator MAML1 of multiple tumor-promoting signaling pathways, which was conducive to cell proliferation and metastasis. Here, HNRNPA2B1 is linked to neoplasm.