In addition to the common mutations (e.g. H3F3A, TP53, ATRX), the clones showed several shared mutations, not identified in the bulk and in the patient tumour tissue (e.g. MAX, KMT2D, SETD1B), and clone-specific mutations (e.g. AMER1, WINT11) (Fig. 2A, B). Here, TP53 is linked to neoplasm.