Given the well-established molecular link between Sirt1 and PPARG signaling [28] and the detrimental role played by PPARG in the context of MCM [8], we examined PPARG and PPARG-dependent genes LPL, PLIN, CD36, FAS and PPARA in cardiac specimens from diabetics and controls (Fig. 5). Here, SIRT1 is linked to diabetes mellitus.