To investigate the role of the Wnt/β-catenin pathway in IGFBP2 promoting HCC EMT, we examined the effects of specific activator of Wnt/β-catenin signaling on the expression of mesenchymal markers in HCCLM3/si-NC and HCCLM3/si-IGFBP2 cells (Fig. 3F). Here, IGFBP2 is linked to hepatocellular carcinoma.