Consistently, IGFBP2 promoted invasion and metastasis of pancreatic ductal adenocarcinoma by PI3K/Akt/IKKβ/NF-κB pathway [24], Notably, publication showed that IGFBP2 knockdown resulted in significant changes in the expression of genes associated with several pathways, cell cycle, p53 and Wnt pathways. This evidence concerns the gene IKBKB and pancreatic ductal adenocarcinoma.