Consistently, IGFBP2 promoted invasion and metastasis of pancreatic ductal adenocarcinoma by PI3K/Akt/IKKβ/NF-κB pathway [24], Notably, publication showed that IGFBP2 knockdown resulted in significant changes in the expression of genes associated with several pathways, cell cycle, p53 and Wnt pathways. The gene discussed is TP53; the disease is pancreatic ductal adenocarcinoma.