Hyperinsulinemia not only increases the secretion of gonadotropins and adrenocorticotropic hormone, but also increase androgen secretion by co-stimulating the production of ovarian and adrenal hormones, and hyperandrogenemia occurs [39]; hyperandrogenism in turn further leads to visceral/abdominal fat deposition, aggravating insulin resistance and hyperinsulinemia [40]. This evidence concerns the gene POMC and Insulin resistance.