CHEK1 and colorectal carcinoma: Similar study also found that overexpression of miR-15a in the exosomes derived from ADMSCs could impair the viability of CRC cells, and promote the apoptosis of CRC cells by downregulating KDM4B [136]; the subsequent study also suggested that UcMSCs-derived exosomal miR-15a-5p suppresses EMT and metastasis of cholangiocarcinoma through targeting downregulation of CHEK1 [137].