Lastly, data from preclinical studies reported that CFTR expression/function is involved in the regulation of SARS-CoV-2 replication [57], while the results of a recent retrospective study reported that patients receiving the triple combination elexacaftor/ivacaftor/tezacaftor had a significantly decreased risk of developing acute respiratory failure after becoming infected with COVID-19 [3]. This evidence concerns the gene CFTR and COVID-19.